Statistics

TCRex currently provides prediction models for 96 different epitopes including 91 viral and 5 cancer epitopes. Performance metrics of these prediction models for the latest model version (i.e. version 2020-10-28) are shown in the tables below. Additionally, the validation graphs show the receiver operating characteristic (ROC) curve, the precision-recall (PR) curve, and the main feature importances of each classifier model.

Viral Epitope Nr. of sequences Balanced accuracy AUROC Average precision
HCV ARMILMTHF 66 0.74 ± 0.07 0.86 ± 0.08 0.69 ± 0.12
YellowFeverVirus LLWNGPMAV 474 0.66 ± 0.01 0.79 ± 0.01 0.53 ± 0.03
SARS-CoV-2 TLVPQEHYV 154 0.53 ± 0.03 0.72 ± 0.02 0.42 ± 0.07
SARS-CoV-2 YLNTLTLAV 390 0.58 ± 0.02 0.8 ± 0.01 0.46 ± 0.04
HIV TPQDLNTML 159 0.81 ± 0.02 0.94 ± 0.04 0.87 ± 0.06
SARS-CoV-2 RQLLFVVEV 841 0.57 ± 0.01 0.83 ± 0.01 0.46 ± 0.02
HIV RFYKTLRAEQASQ 210 0.9 ± 0.03 0.99 ± 0.0 0.96 ± 0.01
HIV EIYKRWII 185 0.65 ± 0.02 0.75 ± 0.06 0.52 ± 0.04
HIV LPPIVAKEI 62 0.79 ± 0.04 0.9 ± 0.05 0.78 ± 0.06
Influenza GILGFVFTL 3107 0.68 ± 0.01 0.81 ± 0.01 0.59 ± 0.03
DENV1 GTSGSPIVNR 165 0.75 ± 0.05 0.88 ± 0.04 0.76 ± 0.06
HIV KRWIILGLNK 396 0.65 ± 0.02 0.85 ± 0.04 0.64 ± 0.08
SARS-CoV-2 WICLLQFAY 515 0.64 ± 0.02 0.81 ± 0.02 0.56 ± 0.06
SARS-CoV-2 ITEEVGHTDLMAAY 156 0.57 ± 0.02 0.78 ± 0.02 0.49 ± 0.04
SARS-CoV-2 YLQPRTFLL 315 0.91 ± 0.01 0.97 ± 0.01 0.92 ± 0.01
SARS-CoV-2 KEIDRLNEV 57 0.58 ± 0.02 0.7 ± 0.08 0.43 ± 0.1
SARS-CoV-2 YLDAYNMMI 197 0.62 ± 0.03 0.74 ± 0.03 0.42 ± 0.05
SARS-CoV-2 KTSVDCTMYI 70 0.7 ± 0.05 0.89 ± 0.05 0.72 ± 0.08
CMV TPRVTGGGAM 258 0.7 ± 0.02 0.88 ± 0.03 0.75 ± 0.04
Influenza LPRRSGAAGA 2137 0.54 ± 0.01 0.84 ± 0.01 0.4 ± 0.02
SARS-CoV-2 SEISMDNSPNL 95 0.52 ± 0.01 0.79 ± 0.05 0.45 ± 0.13
HIV QVPLRPMTYK 48 0.64 ± 0.04 0.77 ± 0.11 0.51 ± 0.16
SARS-CoV-2 TPINLVRDL 249 0.64 ± 0.02 0.81 ± 0.03 0.53 ± 0.04
HCV CINGVCWTV 131 0.53 ± 0.03 0.75 ± 0.06 0.37 ± 0.11
SARS-CoV-2 KAYNVTQAF 708 0.61 ± 0.02 0.83 ± 0.01 0.57 ± 0.03
SARS-CoV-2 KLSYGIATV 2149 0.58 ± 0.0 0.84 ± 0.01 0.51 ± 0.01
HIV KAFSPEVIPMF 210 0.73 ± 0.02 0.9 ± 0.01 0.71 ± 0.03
SARS-CoV-2 SSNVANYQK 74 0.61 ± 0.04 0.77 ± 0.04 0.45 ± 0.08
SARS-CoV-2 ILHCANFNV 185 0.61 ± 0.02 0.84 ± 0.03 0.52 ± 0.05
HIV FRDYVDRFYKTLRAEQASQE 367 0.87 ± 0.02 1.0 ± 0.0 0.96 ± 0.01
HIV RLRPGGKKK 31 0.73 ± 0.06 0.89 ± 0.09 0.73 ± 0.2
EBV IVTDFSVIK 46 0.6 ± 0.05 0.83 ± 0.04 0.53 ± 0.05
CMV VTEHDTLLY 277 0.54 ± 0.0 0.78 ± 0.02 0.39 ± 0.04
HIV IIKDYGKQM 54 0.81 ± 0.07 0.95 ± 0.04 0.84 ± 0.07
SARS-CoV-2 LPPAYTNSF 127 0.53 ± 0.02 0.82 ± 0.03 0.45 ± 0.06
HIV FPRPWLHGL 120 0.81 ± 0.02 0.93 ± 0.02 0.83 ± 0.03
HIV RYPLTFGWCF 30 0.52 ± 0.03 0.72 ± 0.13 0.42 ± 0.12
SARS-CoV-2 NQKLIANQF 51 0.76 ± 0.02 0.95 ± 0.02 0.78 ± 0.07
CMV QYDPVAALF 41 0.7 ± 0.06 0.82 ± 0.06 0.6 ± 0.06
SARS-CoV-2 VLWAHGFEL 695 0.65 ± 0.02 0.85 ± 0.02 0.6 ± 0.04
Influenza PKYVKQNTLKLAT 292 0.52 ± 0.01 0.72 ± 0.02 0.36 ± 0.05
EBV YVLDHLIVV 103 0.52 ± 0.02 0.76 ± 0.07 0.44 ± 0.09
SARS-CoV-2 HLVDFQVTI 69 0.61 ± 0.04 0.75 ± 0.06 0.44 ± 0.09
SARS-CoV-2 FADDLNQLTGY 70 0.61 ± 0.04 0.7 ± 0.05 0.44 ± 0.11
SARS-CoV-2 HTTDPSFLGRY 5000 0.7 ± 0.01 0.9 ± 0.01 0.7 ± 0.02
HIV ISPRTLNAW 58 0.61 ± 0.06 0.84 ± 0.03 0.6 ± 0.12
EBV RAKFKQLL 262 0.65 ± 0.02 0.89 ± 0.01 0.69 ± 0.04
HCV ATDALMTGY 177 0.75 ± 0.03 0.91 ± 0.04 0.77 ± 0.06
SARS-CoV-2 FPPTSFGPL 621 0.69 ± 0.01 0.85 ± 0.01 0.61 ± 0.01
SARS-CoV-2 KLWAQCVQL 266 0.55 ± 0.01 0.8 ± 0.02 0.46 ± 0.05
SARS-CoV-2 YFPLQSYGF 357 0.53 ± 0.01 0.79 ± 0.03 0.4 ± 0.04
SARS-CoV-2 TLDSKTQSL 107 0.83 ± 0.06 0.97 ± 0.02 0.88 ± 0.06
SARS-CoV-2 FTISVTTEIL 159 0.55 ± 0.03 0.73 ± 0.03 0.37 ± 0.04
SARS-CoV-2 ALSKGVHFV 129 0.53 ± 0.01 0.79 ± 0.03 0.4 ± 0.09
SARS-CoV-2 LEPLVDLPI 367 0.54 ± 0.01 0.76 ± 0.02 0.35 ± 0.05
SARS-CoV-2 SEPVLKGVKL 80 0.57 ± 0.02 0.79 ± 0.05 0.38 ± 0.1
SARS-CoV-2 KLPDDFTGCV 1160 0.59 ± 0.01 0.84 ± 0.01 0.54 ± 0.02
SARS-CoV-2 IVDTVSALV 36 0.51 ± 0.03 0.76 ± 0.12 0.36 ± 0.18
HTLV1 SFHSLHLLF 131 0.68 ± 0.03 0.81 ± 0.08 0.63 ± 0.08
SARS-CoV-2 FLPRVFSAV 773 0.59 ± 0.02 0.84 ± 0.01 0.51 ± 0.03
SARS-CoV-2 FVDGVPFVV 2420 0.54 ± 0.0 0.77 ± 0.01 0.37 ± 0.01
SARS-CoV-2 FLNRFTTTL 104 0.54 ± 0.03 0.72 ± 0.07 0.38 ± 0.12
SARS-CoV-2 IQYIDIGNY 149 0.56 ± 0.03 0.82 ± 0.04 0.47 ± 0.06
HIV KRWIIMGLNK 75 0.69 ± 0.05 0.85 ± 0.09 0.73 ± 0.12
DENV3/4 GTSGSPIINR 158 0.73 ± 0.02 0.86 ± 0.03 0.75 ± 0.03
EBV EPLPQGQLTAY 36 0.64 ± 0.08 0.91 ± 0.06 0.68 ± 0.18
SARS-CoV-2 SEVGPEHSLAEY 250 0.54 ± 0.01 0.79 ± 0.01 0.42 ± 0.05
HIV FLKEKGGL 156 0.6 ± 0.03 0.76 ± 0.06 0.48 ± 0.1
SARS-CoV-2 QECVRGTTVL 147 0.71 ± 0.02 0.85 ± 0.02 0.66 ± 0.04
HSV2 RPRGEVRFL 63 0.77 ± 0.04 0.92 ± 0.05 0.84 ± 0.08
SARS-CoV-2 IPIQASLPF 104 0.51 ± 0.02 0.74 ± 0.09 0.35 ± 0.11
CMV IPSINVHHY 85 0.7 ± 0.02 0.84 ± 0.04 0.66 ± 0.06
SARS-CoV-2 MPASWVMRI 477 0.62 ± 0.02 0.82 ± 0.01 0.53 ± 0.01
HCV HSKKKCDEL 45 0.77 ± 0.09 0.99 ± 0.01 0.93 ± 0.03
SARS-CoV-2 ILGLPTQTV 198 0.68 ± 0.02 0.83 ± 0.05 0.6 ± 0.08
SARS-CoV-2 KPLEFGATSAAL 344 0.59 ± 0.02 0.8 ± 0.04 0.49 ± 0.07
SARS-CoV-2 TLIGDCATV 467 0.55 ± 0.02 0.73 ± 0.03 0.36 ± 0.04
CMV YSEHPTFTSQY 74 0.59 ± 0.06 0.93 ± 0.04 0.71 ± 0.06
EBV GLCTLVAML 1208 0.66 ± 0.01 0.82 ± 0.02 0.59 ± 0.0
EBV HPVGEADYFEY 32 0.72 ± 0.08 0.86 ± 0.08 0.68 ± 0.13
SARS-CoV-2 FLNGSCGSV 2332 0.61 ± 0.0 0.86 ± 0.01 0.56 ± 0.02
SARS-CoV-2 EILDITPCSF 68 0.63 ± 0.03 0.73 ± 0.06 0.46 ± 0.09
DENV2 GTSGSPIIDK 60 0.61 ± 0.06 0.74 ± 0.08 0.49 ± 0.04
HCV KLVALGINAV 65 0.62 ± 0.05 0.73 ± 0.08 0.51 ± 0.14
HIV HPKVSSEVHI 75 0.69 ± 0.07 0.87 ± 0.08 0.7 ± 0.16
CMV NLVPMVATV 4812 0.56 ± 0.0 0.72 ± 0.01 0.39 ± 0.01
SARS-CoV-2 LLFNKVTLA 39 0.51 ± 0.03 0.76 ± 0.04 0.37 ± 0.1
HIV TPGPGVRYPL 86 0.68 ± 0.04 0.88 ± 0.03 0.74 ± 0.07
CMV QIKVRVKMV 36 0.5 ± 0.0 0.79 ± 0.05 0.4 ± 0.09
SARS-CoV-2 NLNESLIDL 132 0.59 ± 0.03 0.74 ± 0.02 0.42 ± 0.05
SARS-CoV-2 NLDSKVGGNY 45 0.73 ± 0.06 0.96 ± 0.03 0.85 ± 0.05
Cancer Epitope Nr. of sequences Balanced accuracy AUROC Average precision
Melanoma ELAGIGILTV 1035 0.54 ± 0.0 0.72 ± 0.01 0.37 ± 0.03
Multiple Myeloma LLLGIGILV 233 0.58 ± 0.01 0.77 ± 0.04 0.44 ± 0.06
Melanoma FLYNLLTRV 61 0.63 ± 0.08 0.87 ± 0.03 0.59 ± 0.1
Melanoma AMFWSVPTV 82 0.59 ± 0.04 0.78 ± 0.04 0.48 ± 0.12
Melanoma EAAGIGILTV 266 0.69 ± 0.03 0.9 ± 0.01 0.74 ± 0.01