Statistics

TCRex currently provides prediction models for 42 different epitopes including 37 viral and 5 cancer epitopes. Performance metrics of these prediction models are shown in the tables below. Additionally, the validation graphs show the receiver operating characteristic (ROC) curve, the precision-recall (PR) curve, and the main feature importances of each classifier model.

Viral Epitope Nr. of sequences Balanced accuracy AUROC Average precision
CMV IPSINVHHY 55 0.62 ± 0.04 0.78 ± 0.07 0.54 ± 0.12
CMV NLVPMVATV 4515 0.59 ± 0.01 0.76 ± 0.0 0.46 ± 0.01
CMV QIKVRVKMV 36 0.5 ± 0.0 0.77 ± 0.1 0.4 ± 0.1
CMV TPRVTGGGAM 221 0.7 ± 0.02 0.91 ± 0.03 0.76 ± 0.05
CMV VTEHDTLLY 277 0.55 ± 0.02 0.83 ± 0.03 0.47 ± 0.05
CMV YSEHPTFTSQY 74 0.61 ± 0.04 0.86 ± 0.07 0.67 ± 0.09
DENV1 GTSGSPIVNR 165 0.73 ± 0.04 0.89 ± 0.04 0.76 ± 0.06
DENV2 GTSGSPIIDK 60 0.62 ± 0.05 0.8 ± 0.07 0.55 ± 0.05
DENV3/4 GTSGSPIINR 158 0.71 ± 0.03 0.86 ± 0.03 0.73 ± 0.01
EBV EPLPQGQLTAY 36 0.71 ± 0.06 0.87 ± 0.06 0.69 ± 0.09
EBV GLCTLVAML 1252 0.68 ± 0.02 0.84 ± 0.02 0.65 ± 0.03
EBV HPVGEADYFEY 32 0.6 ± 0.08 0.81 ± 0.14 0.53 ± 0.27
EBV IVTDFSVIK 46 0.67 ± 0.04 0.79 ± 0.05 0.56 ± 0.05
EBV RAKFKQLL 262 0.67 ± 0.01 0.88 ± 0.03 0.69 ± 0.06
EBV YVLDHLIVV 103 0.55 ± 0.01 0.75 ± 0.06 0.48 ± 0.07
HCV ARMILMTHF 65 0.71 ± 0.03 0.91 ± 0.03 0.76 ± 0.03
HCV ATDALMTGY 177 0.77 ± 0.03 0.89 ± 0.04 0.75 ± 0.07
HCV CINGVCWTV 125 0.53 ± 0.02 0.75 ± 0.04 0.4 ± 0.08
HCV HSKKKCDEL 45 0.73 ± 0.1 1.0 ± 0.0 0.96 ± 0.02
HIV EIYKRWII 183 0.61 ± 0.02 0.75 ± 0.02 0.45 ± 0.07
HIV FLKEKGGL 147 0.59 ± 0.03 0.77 ± 0.03 0.48 ± 0.04
HIV FPRPWLHGL 123 0.82 ± 0.04 0.93 ± 0.03 0.84 ± 0.04
HIV HPKVSSEVHI 76 0.78 ± 0.07 0.89 ± 0.05 0.79 ± 0.09
HIV IIKDYGKQM 57 0.8 ± 0.07 0.96 ± 0.03 0.88 ± 0.06
HIV ISPRTLNAW 59 0.63 ± 0.03 0.82 ± 0.06 0.56 ± 0.1
HIV KAFSPEVIPMF 211 0.74 ± 0.03 0.89 ± 0.02 0.73 ± 0.05
HIV KRWIILGLNK 354 0.64 ± 0.02 0.87 ± 0.02 0.66 ± 0.04
HIV KRWIIMGLNK 75 0.64 ± 0.02 0.86 ± 0.03 0.69 ± 0.05
HIV LPPIVAKEI 62 0.75 ± 0.1 0.92 ± 0.04 0.74 ± 0.1
HIV QVPLRPMTYK 48 0.64 ± 0.04 0.8 ± 0.09 0.52 ± 0.16
HIV RYPLTFGWCF 30 0.5 ± 0.0 0.7 ± 0.08 0.46 ± 0.15
HIV TPGPGVRYPL 63 0.6 ± 0.05 0.89 ± 0.06 0.71 ± 0.12
HIV TPQDLNTML 159 0.81 ± 0.04 0.93 ± 0.03 0.86 ± 0.05
HSV2 RPRGEVRFL 43 0.77 ± 0.09 0.91 ± 0.06 0.79 ± 0.11
Influenza A GILGFVFTL 2922 0.69 ± 0.0 0.84 ± 0.01 0.65 ± 0.02
Influenza A LPRRSGAAGA 2137 0.55 ± 0.01 0.87 ± 0.01 0.44 ± 0.02
YellowFeverVirus LLWNGPMAV 353 0.7 ± 0.01 0.85 ± 0.03 0.64 ± 0.06
Cancer Epitope Nr. of sequences Balanced accuracy AUROC Average precision
Melanoma AMFWSVPTV 82 0.58 ± 0.05 0.76 ± 0.05 0.47 ± 0.11
Melanoma EAAGIGILTV 265 0.68 ± 0.02 0.89 ± 0.02 0.7 ± 0.03
Melanoma ELAGIGILTV 1012 0.55 ± 0.0 0.75 ± 0.02 0.43 ± 0.02
Melanoma FLYNLLTRV 61 0.6 ± 0.05 0.85 ± 0.05 0.52 ± 0.12
Multiple myeloma LLLGIGILV 233 0.58 ± 0.01 0.81 ± 0.04 0.5 ± 0.06