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Statistics

TCRex currently provides prediction models for 100 different epitopes including 93 viral and 7 cancer epitopes. Performance metrics of these prediction models for the latest model version (i.e. version 2023-06-26) are shown in the tables below. Additionally, the validation graphs show the receiver operating characteristic (ROC) curve, the precision-recall (PR) curve, and the main feature importances of each classifier model.

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Viral	Epitope	Nr. of sequences	Balanced accuracy	AUROC	Average precision
CMV	IPSINVHHY	85	0.7 ± 0.02	0.84 ± 0.04	0.66 ± 0.06
CMV	NLVPMVATV	4812	0.56 ± 0.0	0.72 ± 0.01	0.39 ± 0.01
CMV	QIKVRVKMV	36	0.5 ± 0.0	0.79 ± 0.05	0.4 ± 0.09
CMV	QYDPVAALF	41	0.7 ± 0.06	0.82 ± 0.06	0.6 ± 0.06
CMV	TPRVTGGGAM	258	0.7 ± 0.02	0.88 ± 0.03	0.75 ± 0.04
CMV	VTEHDTLLY	277	0.54 ± 0.0	0.78 ± 0.02	0.39 ± 0.04
CMV	YSEHPTFTSQY	74	0.59 ± 0.06	0.93 ± 0.04	0.71 ± 0.06
DENV1	GTSGSPIVNR	165	0.75 ± 0.05	0.88 ± 0.04	0.76 ± 0.06
DENV2	GTSGSPIIDK	60	0.61 ± 0.06	0.74 ± 0.08	0.49 ± 0.04
DENV3/4	GTSGSPIINR	158	0.73 ± 0.02	0.86 ± 0.03	0.75 ± 0.03
EBV	EPLPQGQLTAY	36	0.64 ± 0.08	0.91 ± 0.06	0.68 ± 0.18
EBV	GLCTLVAML	1208	0.66 ± 0.01	0.82 ± 0.02	0.59 ± 0.0
EBV	HPVGEADYFEY	32	0.72 ± 0.08	0.86 ± 0.08	0.68 ± 0.13
EBV	IVTDFSVIK	46	0.6 ± 0.05	0.83 ± 0.04	0.53 ± 0.05
EBV	RAKFKQLL	262	0.65 ± 0.02	0.89 ± 0.01	0.69 ± 0.04
EBV	YVLDHLIVV	103	0.52 ± 0.02	0.76 ± 0.07	0.44 ± 0.09
HCV	ARMILMTHF	66	0.74 ± 0.07	0.86 ± 0.08	0.69 ± 0.12
HCV	ATDALMTGY	177	0.75 ± 0.03	0.91 ± 0.04	0.77 ± 0.06
HCV	CINGVCWTV	131	0.53 ± 0.03	0.75 ± 0.06	0.37 ± 0.11
HCV	HSKKKCDEL	45	0.77 ± 0.09	0.99 ± 0.01	0.93 ± 0.03
HCV	KLVALGINAV	65	0.62 ± 0.05	0.73 ± 0.08	0.51 ± 0.14
HIV	EIYKRWII	185	0.65 ± 0.02	0.75 ± 0.06	0.52 ± 0.04
HIV	FLKEKGGL	156	0.6 ± 0.03	0.76 ± 0.06	0.48 ± 0.1
HIV	FPRPWLHGL	120	0.81 ± 0.02	0.93 ± 0.02	0.83 ± 0.03
HIV	FRDYVDRFYKTLRAEQASQE	367	0.87 ± 0.02	1.0 ± 0.0	0.96 ± 0.01
HIV	HPKVSSEVHI	75	0.69 ± 0.07	0.87 ± 0.08	0.7 ± 0.16
HIV	IIKDYGKQM	54	0.81 ± 0.07	0.95 ± 0.04	0.84 ± 0.07
HIV	ISPRTLNAW	58	0.61 ± 0.06	0.84 ± 0.03	0.6 ± 0.12
HIV	KAFSPEVIPMF	210	0.73 ± 0.02	0.9 ± 0.01	0.71 ± 0.03
HIV	KRWIILGLNK	396	0.65 ± 0.02	0.85 ± 0.04	0.64 ± 0.08
HIV	KRWIIMGLNK	75	0.69 ± 0.05	0.85 ± 0.09	0.73 ± 0.12
HIV	LPPIVAKEI	62	0.79 ± 0.04	0.9 ± 0.05	0.78 ± 0.06
HIV	QVPLRPMTYK	48	0.64 ± 0.04	0.77 ± 0.11	0.51 ± 0.16
HIV	RFYKTLRAEQASQ	210	0.9 ± 0.03	0.99 ± 0.0	0.96 ± 0.01
HIV	RLRPGGKKK	31	0.73 ± 0.06	0.89 ± 0.09	0.73 ± 0.2
HIV	RYPLTFGWCF	30	0.52 ± 0.03	0.72 ± 0.13	0.42 ± 0.12
HIV	TPGPGVRYPL	86	0.68 ± 0.04	0.88 ± 0.03	0.74 ± 0.07
HIV	TPQDLNTML	159	0.81 ± 0.02	0.94 ± 0.04	0.87 ± 0.06
HSV2	RPRGEVRFL	63	0.77 ± 0.04	0.92 ± 0.05	0.84 ± 0.08
HTLV1	SFHSLHLLF	131	0.68 ± 0.03	0.81 ± 0.08	0.63 ± 0.08
Influenza	GILGFVFTL	3107	0.68 ± 0.01	0.81 ± 0.01	0.59 ± 0.03
Influenza	LPRRSGAAGA	2137	0.54 ± 0.01	0.84 ± 0.01	0.4 ± 0.02
Influenza	PKYVKQNTLKLAT	292	0.52 ± 0.01	0.72 ± 0.02	0.36 ± 0.05
SARS-CoV-2	ALSKGVHFV	129	0.53 ± 0.01	0.79 ± 0.03	0.4 ± 0.09
SARS-CoV-2	EILDITPCSF	68	0.63 ± 0.03	0.73 ± 0.06	0.46 ± 0.09
SARS-CoV-2	FADDLNQLTGY	70	0.61 ± 0.04	0.7 ± 0.05	0.44 ± 0.11
SARS-CoV-2	FLNGSCGSV	2332	0.61 ± 0.0	0.86 ± 0.01	0.56 ± 0.02
SARS-CoV-2	FLNRFTTTL	104	0.54 ± 0.03	0.72 ± 0.07	0.38 ± 0.12
SARS-CoV-2	FLPRVFSAV	773	0.59 ± 0.02	0.84 ± 0.01	0.51 ± 0.03
SARS-CoV-2	FPPTSFGPL	621	0.69 ± 0.01	0.85 ± 0.01	0.61 ± 0.01

Showing 1 to 50 of 93 entries

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Cancer	Epitope	Nr. of sequences	Balanced accuracy	AUROC	Average precision
Melanoma	AMFWSVPTV	82	0.59 ± 0.04	0.78 ± 0.04	0.48 ± 0.12
Melanoma	EAAGIGILTV	266	0.69 ± 0.03	0.9 ± 0.01	0.74 ± 0.01
Melanoma	ELAGIGILTV	1035	0.54 ± 0.0	0.72 ± 0.01	0.37 ± 0.03
Melanoma	FLYNLLTRV	61	0.63 ± 0.08	0.87 ± 0.03	0.59 ± 0.1
Multiple Myeloma	LLLGIGILV	233	0.58 ± 0.01	0.77 ± 0.04	0.44 ± 0.06
Tumor associated antigen (WT1)	RMFPNAPYL	101	0.58 ± 0.03	0.69 ± 0.11	0.49 ± 0.15
Tumor associated antigen (WT1)	VLDFAPPGA	1262	0.56 ± 0.01	0.8 ± 0.02	0.49 ± 0.03

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